Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

0534516 - ÚFCH JH 2021 RIV US eng J - Článek v odborném periodiku
Wang, J. T. W. - Klippstein, R. - Martincic, M. - Pach, E. - Feldman, R. - Šefl, M. - Michel, Y. - Asker, D. - Sosabowski, J. K. - Kalbáč, Martin - Da Ros, T. - Menard-Moyon, C. - Bianco, A. - Kyriakou, I. - Emfietzoglou, D. - Saccavini, J.-C. - Ballesteros, B. - Al-Jamal, K. T. - Tobias, G.
Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy.
ACS Nano. Roč. 14, č. 1 (2020), s. 129-141. ISSN 1936-0851. E-ISSN 1936-086X
Grant CEP: GA MŠMT(CZ) LTC18039; GA MŠMT(CZ) EF16_013/0001821
GRANT EU: European Commission(XE) 290023
Grant ostatní: GA MŠk(CZ) CZ.02.1.01/0.0/0.0/16_013/0001821
Institucionální podpora: RVO:61388955
Klíčová slova: mesoporous silica nanoparticles * holmium nanoparticles * nanotubes * encapsulation * vitro * metastases * strategies * samarium * behavior * biology * cancer therapy * nuclear imaging * nanoencapsulation * filled carbon nanotubes * radiooncology * nanooncology
Obor OECD: Physical chemistry
Impakt faktor: 15.881, rok: 2020
Způsob publikování: Open access s časovým embargem

Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing ´cold´ isotopically enriched samarium (Sm-152), which can then be activated on demand to their ´hot´ radioactive form (Sm-153) by neutron irradiation. The use of ´cold´ isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the ´hot´ nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.
Trvalý link: http://hdl.handle.net/11104/0312700