Počet záznamů: 1
The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
- 1.0534257 - FGÚ 2021 RIV CH eng J - Článek v odborném periodiku
Kosek, V. - Heczková, M. - Novák, F. - Meisnerová, E. - Nováková, Olga - Zelenka, J. - Bechyňská, K. - Vrzáčová, N. - Suttnar, J. - Hlaváčková, A. - Danková, H. - Bratová, M. - Dasková, N. - Malínská, H. - Oliyarnyk, O. - Wohl, P. - Bastová, H. - Hajslová, J. - Cahová, M.
The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach.
Nutrients. Roč. 12, č. 8 (2020), č. článku 2351. ISSN 2072-6643. E-ISSN 2072-6643
Institucionální podpora: RVO:67985823
Klíčová slova: home parenteral nutrition * intestinal failure * fish oil * olive oil * oxidative stress * lipidomics * hydroxy-fatty acids * plasmalogens * lipidomics
Obor OECD: Nutrition, Dietetics
Impakt faktor: 5.719, rok: 2020
Způsob publikování: Open access
https://www.mdpi.com/2072-6643/12/8/2351
Omega-3 polyunsaturated fatty acids (omega-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered omega-3 PUFAs without (FO/-,n= 9) or with (FO/OO,n= 13) olive oil and healthy age- and sex-matched controls, (n= 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/- and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/- subcohort. The lipidome of all subjects receiving omega-3 PUFAs was enriched with lipid species containing omega-3 PUFAs (FO/->FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/-. We confirmed the protective effect of OO in PN mixtures containing omega-3 PUFAs.
Trvalý link: http://hdl.handle.net/11104/0312480
Počet záznamů: 1