Al(iii)-NTA-fluoride: A simple model system for Al-F binding with interesting thermodynamics

0533646 - ÚOCHB 2021 RIV GB eng J - Článek v odborném periodiku
Hacaperková, E. - Jaroš, Adam - Kotek, J. - Notni, J. - Straka, Michal - Kubíček, V. - Hermann, P.
Al(iii)-NTA-fluoride: A simple model system for Al-F binding with interesting thermodynamics.
Dalton Transactions. Roč. 49, č. 39 (2020), s. 13726-13736. ISSN 1477-9226. E-ISSN 1477-9234
Grant CEP: GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: density functional methods * correlation energy * complexes
Obor OECD: Physical chemistry
Impakt faktor: 4.390, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1039/D0DT02644A

Al(III) complexes are extensively studied as [18F]fluoride carriers in positron emission tomography. However, our limited knowledge on their thermodynamic and kinetic properties has hindered efforts to easily prepare radiochemically pure compounds while simultaneously reducing the overall labeling time. Thus, to improve our understanding of fluoride binding to coordinatively unsaturated Al(III) complexes, we investigated the ternary system Al(III)–H3NTA–F− (H3NTA = nitrilo-triacetic acid) by NMR, potentiometry and X-ray diffraction. Our results show that the [Al(NTA)] complex binds two water molecules, which are replaced by fluorides. Individual species and isomers show separate 19F NMR signals and different stability constants. The two available positions on the [Al(NTA)] complex feature significantly different properties in terms of basicity of the coordinated water molecules and preferential binding of fluoride anions. Fluorides are effectively bound in weakly acidic or neutral solutions, whereas hydroxido species are preferentially formed in alkaline solutions. Our experimental observations were rationalized by theoretical calculations: predictions of the energy ordering of complexes and isomers, interpretation of 19F NMR chemical shifts, and natural bonding orbital analysis. Radiolabeling of [Al(NTA)] with [18F]fluoride gave low yields that confirmed a high affinity of the complex for hydroxide anions.
Trvalý link: http://hdl.handle.net/11104/0312372