Počet záznamů: 1  

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

  1. 1.
    0533527 - ÚŽFG 2021 RIV GB eng J - Článek v odborném periodiku
    Křivánek, J. - Soldatov, R. A. - Kastriti, M.E. - Chontorotzea, T. - Herdina, A. N. - Petersen, J. - Szarowská, B. - Landová, Marie - Kovář Matějová, V. - Izakovičová Hollá, L. - Kuchler, U. - Vidovic Zdrilic, I. - Vijaykumar, A. - Balic, A. - Marangoni, P. - Klein, O. D. - Neves, V. C. M. - Yianni, V. - Sharpe, P. T. - Harkany, T. - Metscher, B. D. - Bajénoff, M. - Mina, M. - Fried, K. - Kharchenko, V. A. - Adameyko, I.
    Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
    Nature Communications. Roč. 11, č. 1 (2020), č. článku 4816. E-ISSN 2041-1723
    Institucionální podpora: RVO:67985904
    Klíčová slova: tooth development * dental growth * mouse teeth
    Obor OECD: Cell biology
    Impakt faktor: 14.919, rok: 2020
    Způsob publikování: Open access
    https://www.nature.com/articles/s41467-020-18512-7

    Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.
    Trvalý link: http://hdl.handle.net/11104/0311900

     
     
Počet záznamů: 1  

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