The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

0533335 - ÚOCHB 2021 RIV GB eng J - Článek v odborném periodiku
Dzianová, P. - Asai, Seiya - Chrudinová, Martina - Kosinová, L. - Potalitsyn, Pavlo - Šácha, Pavel - Hadravová, Romana - Selicharová, Irena - Kříž, J. - Turkenburg, J. P. - Brzozowski, A. M. - Jiráček, Jiří - Žáková, Lenka
The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels.
Open Biology. Roč. 10, č. 10 (2020), č. článku 200137. E-ISSN 2046-2441
Grant CEP: GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: insulin * zinc * beta cells * production ZnT8
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 6.411, rok: 2020
Způsob publikování: Open access
https://doi.org/10.1098/rsob.200137

Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However,the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. We showed that the disruption of zinc homeostasis in the model β-cells correlated with their impaired insulin and ZnT8 production. This indicates a need for in-depth fundamental research about the role of zinc in insulin production and storage.
Trvalý link: http://hdl.handle.net/11104/0311840