A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof

0533071 - ÚSMH 2021 RIV eng P - Patentový dokument
Suchý, Tomáš - Šupová, Monika - Denk, František - Rýglová, Šárka - Žaloudková, Margit - Sucharda, Zbyněk - Ballay, R. - Horný, L. - Čejka, Z. - Pokorný, M. - Knotková, K. - Velebný, V.
A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof.
2020. Vlastník: Ústav struktury a mechaniky hornin AV ČR, v. v. i. - České vysoké učení technické v Praze, Fakulta strojní - ProSpon spol. s.r.o. - Contipro a.s. Datum udělení patentu: 05.08.2020. Číslo patentu: EP3311854
Grant CEP: GA TA ČR(CZ) TA04010330
Institucionální podpora: RVO:67985891
Klíčová slova: Collagen * Layer * Composite * Nanofiber * Electrospining
Obor OECD: Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200805&DB=&locale=en_EP&CC=EP&NR=3311854B1&KC=B1&ND=1#

The subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics.
Trvalý link: http://hdl.handle.net/11104/0311567