Amphipilic compounds with neuroprotective properties

0533018 - ÚOCHB 2021 RIV eng P - Patentový dokument
Chodounská, Hana - Jahn, Ullrich - Kapras, Vojtěch - Kudová, Eva - Valeš, Karel - Vyklický ml., Ladislav
Amphipilic compounds with neuroprotective properties.
2020. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Datum udělení patentu: 30.06.2020. Číslo patentu: CA3013725
Grant CEP: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:61388963 ; RVO:67985823
Klíčová slova: steroid * NMDA receptor * neuroprotective
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=CA&NR=3013725C&KC=C&FT=D&ND=4&date=20200630&DB=&locale=en_EP

The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton of general formula I, and their enantiomers, wherein R1, R2, 115, R4 and R5 are as defined herein, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
Trvalý link: http://hdl.handle.net/11104/0311550