Počet záznamů: 1
Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use
- 1.0532862 - ÚOCHB 2021 RIV eng P - Patentový dokument
Hocek, Michal - Tokarenko, Anna - Smolen, Sabina - Hajdúch, M. - Džubák, P.
Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use.
2020. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Datum udělení patentu: 07.07.2020. Číslo patentu: CA3031049
Grant CEP: GA ČR(CZ) GA16-00178S; GA TA ČR(CZ) TE01020028
Institucionální podpora: RVO:61388963
Klíčová slova: nucleosides * cytostatics * deazapurines
Obor OECD: Medicinal chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=CA&NR=3031049C&KC=C&FT=D&ND=4&date=20200707&DB=&locale=en_EP
Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula (I), where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines in a wide variety of diseases including tumors of various histogenic origin.
Trvalý link: http://hdl.handle.net/11104/0311279
Počet záznamů: 1