Narcissistic T cells: reactivity to self makes a difference

0531950 - ÚMG 2022 RIV US eng J - Článek v odborném periodiku
Paprčková, Darina - Štěpánek, Ondřej
Narcissistic T cells: reactivity to self makes a difference.
FEBS Journal. Roč. 288, č. 6 (2021), s. 1778-1788. ISSN 1742-464X. E-ISSN 1742-4658
Grant CEP: GA ČR GJ19-03435Y
Institucionální podpora: RVO:68378050
Klíčová slova: aimt * cd5 * nur77 * self-antigen * self-reactivity * T cell * tcr * tolerance * virtual memory
Obor OECD: Immunology
Impakt faktor: 5.622, rok: 2021
Způsob publikování: Open access
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498

It has been appreciated for more than three decades that the interactions between the T-cell antigen receptor and self-antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self-reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self-reactivity of their antigen receptors. Overall, the relative difference in the self-reactivity among peripheral T cells is an important factor contributing to the diversity of T-cell responses to foreign antigens.
Trvalý link: http://hdl.handle.net/11104/0310576