Norepinephrine transporter-derived homing peptides enable rapid endocytosis of drug delivery nanovehicles into neuroblastoma cells

0531791 - ÚVGZ 2021 RIV GB eng J - Článek v odborném periodiku
Haddad, Y. - Charousova, M. - Životská, H. - Splichal, Z. - Rodrigo, M. A. M. - Michalkova, H. - Křížková, S. - Tesarova, B. - Richtera, L. - Vítek, Petr - Stokowa-Soltys, K. - Hynek, D. - Milosavljevic, V. - Rex, S. - Heger, Z.
Norepinephrine transporter-derived homing peptides enable rapid endocytosis of drug delivery nanovehicles into neuroblastoma cells.
Journal of Nanobiotechnology. Roč. 18, č. 1 (2020), č. článku 95. E-ISSN 1477-3155
Grant CEP: GA MŠMT(CZ) LM2018123
Výzkumná infrastruktura: CzeCOS III - 90123
Institucionální podpora: RVO:86652079
Klíčová slova: web server * secondary structure * protein * growth * recognition * apoferritin * nanocarrier * strategies * apoptosis * dopamine * Homing peptide * Ferritin * Neuroblastoma * Norepinephrine transporter * Targeted therapy
Obor OECD: Environmental biotechnology
Impakt faktor: 10.435, rok: 2020
Způsob publikování: Open access
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-00654-x

Background: Currently, the diagnosis and treatment of neuroblastomas-the most frequent solid tumors in children-exploit the norepinephrine transporter (hNET) via radiolabeled norepinephrine analogs. We aim to develop a nanomedicine-based strategy towards precision therapy by targeting hNET cell-surface protein with hNET-derived homing peptides.
Trvalý link: http://hdl.handle.net/11104/0310482