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Mitotic chromosome organization: General rules meet species-specific variability
- 1.0531604 - ÚEB 2021 RIV SE eng J - Článek v odborném periodiku
Beseda, Tomáš - Cápal, Petr - Kubalová, I. - Schubert, V. - Doležel, Jaroslav - Šimková, Hana
Mitotic chromosome organization: General rules meet species-specific variability.
Computational and Structural Biotechnology Journal. Roč. 18, FEB 3 (2020), s. 1311-1319. ISSN 2001-0370. E-ISSN 2001-0370
Grant CEP: GA MŠMT(CZ) EF16_019/0000827
Institucionální podpora: RVO:61389030
Klíčová slova: Chromatin fiber folding * Chromosome cavities * Chromosome condensation * Chromosome conformation capture * Chromosome scaffold * Structural maintenance of chromosomes proteins
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 7.271, rok: 2020
Způsob publikování: Open access
http://doi.org/10.1016/j.csbj.2020.01.006
Research on the formation of mitotic chromosomes from interphase chromatin domains, ongoing for several decades, made significant progress in recent years. It was stimulated by the development of advanced microscopic techniques and implementation of chromatin conformation capture methods that provide new insights into chromosome ultrastructure. This review aims to summarize and compare several models of chromatin fiber folding to form mitotic chromosomes and discusses them in the light of the novel findings. Functional genomics studies in several organisms confirmed condensins and cohesins as the major players in chromosome condensation. Here we compare available data on the role of these proteins across lower and higher eukaryotes and point to differences indicating evolutionary different pathways to shape mitotic chromosomes. Moreover, we discuss a controversial phenomenon of the mitotic chromosome ultrastructure – chromosome cavities – and using our super-resolution microscopy data, we contribute to its elucidation.
Trvalý link: http://hdl.handle.net/11104/0310236
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