Physical study of proton therapy at CANAM laboratory on medulloblastoma cell lines DAOY

0531352 - ÚJF 2021 RIV GB eng J - Článek v odborném periodiku
Torrisi, L. - Davídková, Marie - Cutroneo, Mariapompea - Torrisi, Alfio
Physical study of proton therapy at CANAM laboratory on medulloblastoma cell lines DAOY.
Radiation Effects and Defects in Solids. Roč. 175, 9-10 (2020), s. 863-878. ISSN 1042-0150. E-ISSN 1029-4953
Grant CEP: GA MŠMT LM2015056; GA ČR(CZ) GBP108/12/G108; GA ČR GA19-02482S; GA MŠMT EF16_013/0001812
Institucionální podpora: RVO:61389005
Klíčová slova: protontherapy * Bragg peak * medulloblastoma cell line DAOY * proton dose
Obor OECD: Radiology, nuclear medicine and medical imaging
Impakt faktor: 1.141, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1080/10420150.2020.1780592

2.0 MeV proton beam accelerated at Tandetron is extracted in air through a thin film and allowed to scatter to irradiate the cell culture attached to the polymeric base of a biological flask. The irradiated cells were human medulloblastoma cell line Daoy treated with and without 5 nm sized spherical gold nanoparticles. Proton doses from 0.5 to 1.5 Gy have been employed to irradiate the cultures and to investigate the role of the radiotherapy performed with and without the use of the gold nanoparticles. Results indicated that cell survival is significantly reduced to about 50% when the nanoparticles at a concentration of about 6 x 10(13)particles/ml are employed.
Trvalý link: http://hdl.handle.net/11104/0312132