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The pharmaceutical ability of Pistacia lentiscus L. Leaves essential oil against periodontal bacteria and Candida sp. and its anti-inflammatory potential
- 1.0531297 - ÚEB 2021 RIV CH eng J - Článek v odborném periodiku
Milia, E. - Usai, C. - Szotáková, B. - Elstnerová, M. - Králová, V. - D’hallewin, G. - Spissu, Y. - Barberis, A. - Marchetti, M. - Bortone, A. - Campanella, V. - Mastandrea, G. - Langhansová, Lenka - Eick, S.
The pharmaceutical ability of Pistacia lentiscus L. Leaves essential oil against periodontal bacteria and Candida sp. and its anti-inflammatory potential.
Antibiotics (Basel). Roč. 9, č. 6 (2020), č. článku 281. ISSN 2079-6382. E-ISSN 2079-6382
Grant CEP: GA MŠMT(CZ) LTC17035
Institucionální podpora: RVO:61389030
Klíčová slova: Candida albicans * Candida glabrata * Cyclooxygenase * Lipoxygenase * Medicinal herbs * Oral health care products * Periodontal disease
Obor OECD: Medical laboratory technology (including laboratory samples analysis
Impakt faktor: 4.639, rok: 2020
Způsob publikování: Open access
http://doi.org/10.3390/antibiotics9060281
Background: Given the increasing request for natural pharmacological molecules, this study assessed the antimicrobial capacity of Pistacialentiscus L. essential oil (PLL-EO) obtained from the leaves of wild plants growing in North Sardinia (Italy) toward a wide range of periodontal bacteria and Candida, including laboratory and clinical isolates sp., together with its antiinflammatory activity and safety. Methods: PLL-EO was screened by gas chromatography/mass spectrometry. The minimal inhibitory concentration (MIC) was determined. The anti-inflammatory activity was measured by cyclooxygenase (COX-1/2) and lipoxygenase (LOX) inhibition, while the antioxidant capacity was determined electro-chemically and by the MTT assay. The WST-1 assay was used to ascertain cytotoxicity toward four lines of oral cells. Results: According to the concentrations of terpens, PLL-EO is a pharmacologically-active phytocomplex. MICs against periodontal bacteria ranged between 3.13 and 12.5 µg/ml, while against Candida sp. they were between 6.25 and 12.5 µg/mL. Oxidation by COX-1/2 and LOX was inhibited by 80% and 20% µg/mL of the oil, respectively. Antioxidant activity seemed negligible, and no cytotoxicity arose. CONCLUSIONS: PLL-EO exhibits a broad-spectrum activity against periodontal bacteria and Candida, with an interesting dual inhibitory capacity toward COX-2 and LOX inflammatory enzymes, and without side effects against oral cells.
Trvalý link: http://hdl.handle.net/11104/0309982
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