The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

0531162 - MBÚ 2021 RIV US eng J - Článek v odborném periodiku
Schafer, H. - Beckert, B. - Frese, Ch.K. - Steinchen, W. - Nuss, A.M. - Beckstette, M. - Hantke, I. - Driller, K. - Sudzinová, Petra - Krásný, Libor - Kaever, V. - Dersch, P. - Bange, G. - Wilson, D.N. - Turgay, K.
The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.
PLoS Genetics. Roč. 16, č. 3 (2020), č. článku e1008275. ISSN 1553-7404. E-ISSN 1553-7404
Grant CEP: GA ČR(CZ) GA19-12956S; GA MŠMT(CZ) LM2015055
Institucionální podpora: RVO:61388971
Klíčová slova: nutritional stress activation * protein-quality control * stringent response
Obor OECD: Microbiology
Impakt faktor: 5.917, rok: 2020
Způsob publikování: Open access
https://journals.plos.org/plosgenetics/article?rev=1&id=10.1371/journal.pgen.1008275

We observed that the second messenger (p)ppGpp, known to be synthesized by the ribosome-associated Rel synthetase upon nutrient starvation during the stringent response, is also intricately involved in the stress response of B. subtilis cells and can act as a pleiotropic regulator during the adaptation to heat stress. (p)ppGpp can slow down and modulate translation and is, together with the transcriptional stress regulator Spx, partially involved in the transcriptional down-regulation of the translation machinery. The stress-induced elevation of cellular (p)ppGpp levels confers increased stress tolerance and facilitates an improved protein homeostasis by modulating translation and reducing the load on the protein quality control system.
Trvalý link: http://hdl.handle.net/11104/0309884