Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

0525375 - BTÚ 2021 RIV NL eng J - Článek v odborném periodiku
Boukalová, Štěpána - Hubáčková, Soňa - Miloševič, Mirko - Ezrová, Zuzana - Neužil, Jiří - Rohlena, Jakub
Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer.
Biochimica Et Biophysica Acta-Molecular Basis of Disease. Roč. 1866, č. 6 (2020), č. článku 165759. ISSN 0925-4439. E-ISSN 1879-260X
Grant CEP: GA ČR GA19-20553S; GA ČR(CZ) GA20-18513S; GA ČR(CZ) GA18-02550S; GA ČR(CZ) GJ20-11724Y; GA ČR(CZ) GC17-01192J; GA ČR(CZ) GA18-10832S; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036
Klíčová slova: Dehydroorotate dehydrogenase * Oxidative phosphorylation * Cancer
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 5.187, rok: 2020
Způsob publikování: Open access
https://www.sciencedirect.com/science/article/pii/S0925443920301046?via%3Dihub

Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
Trvalý link: http://hdl.handle.net/11104/0309534