Počet záznamů: 1  

The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease

  1. 1.
    0525370 - MBÚ 2021 RIV DE eng J - Článek v odborném periodiku
    Dotlačil, J. - Bronský, J. - Hradský, O. - Frýbová, B. - Coufal, Štěpán - Škába, R. - Rýgl, M.
    The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease.
    European Journal of Pediatric Surgery. Roč. 30, č. 1 (2020), s. 27-32. ISSN 0939-7248. E-ISSN 1439-359X
    Institucionální podpora: RVO:61388971
    Klíčová slova: pediatric surgery * Crohn's disease * anti-tumor necrosis factor alpha
    Obor OECD: Microbiology
    Impakt faktor: 2.191, rok: 2020
    Způsob publikování: Omezený přístup
    https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1697909

    Introduction The incidence of Crohn's disease (CD) within the pediatric population is increasing worldwide. Despite a growing number of these patients receiving anti-tumor necrosis factor alpha therapy (anti-TNF-alpha), one-third of them still require surgery. There is limited data as to whether anti-TNF-alpha influences postoperative complications. We evaluated postoperative complications in patients who were or were not exposed to anti-TNF-alpha therapy in our institutional cohort.

    Materials and Methods A retrospective review of CD patients who underwent abdominal surgery between September 2013 and September 2018 was performed. The patients were divided into two groups based on whether they were treated with anti-TNF-alpha within 90 days before surgery. Thirty-day postoperative complications were assessed using Clavien-Dindo classification (D-C), this examination included surgical site infections (SSIs), stoma complications, intra-abdominal septic complications, non-SSIs, bleeding, ileus, readmission rate, and return to the operating room. Mann-Whitney U -test, Fisher's exact test, and multivariate logistic regression analyses were used for statistical analysis.

    Results Sixty-five patients (41 males) with a median age of 16 years (range: 7-19) at the time of operation were identified. The most common surgery was ileocecal resection in 49 (75%) patients. Forty-three (66.2%) patients were treated with anti-TNF-alpha preoperatively. Seven patients (11%) experienced postoperative complications. There was no statistically significant difference in postoperative complication in patients who did or did not receive anti-TNF-alpha before surgery (D-C minor 2.3% vs. 4.6%, p = 1, D-C major 7% vs. 9.1%, p = 1).

    Conclusion The use of anti-TNF-alpha in pediatric CD patients within the 90 days prior to their abdominal surgery was not associated with an increased risk of 30-day postoperative complications.
    Trvalý link: http://hdl.handle.net/11104/0309529

     
     
Počet záznamů: 1  

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