Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice

0524894 - FGÚ 2021 RIV US eng J - Článek v odborném periodiku
Palůchová, Veronika - Vik, A. - Čajka, Tomáš - Březinová, Marie - Brejchová, Kristýna - Bugajev, Viktor - Dráberová, Lubica - Dráber, Peter - Burešová, Jana - Kroupová, Petra - Bardová, Kristina - Rossmeisl, Martin - Kopecký, Jan - Hansen, T. V. - Kuda, Ondřej
Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice.
Molecular Nutrition & Food Research. Roč. 64, č. 11 (2020), č. článku 1901238. ISSN 1613-4125. E-ISSN 1613-4133
Grant CEP: GA ČR(CZ) GJ17-10088Y; GA ČR(CZ) GA17-20255S; GA ČR(CZ) GA17-20915S; GA ČR GA18-18521S; GA ČR(CZ) GA20-00317S
Grant ostatní: AV ČR(CZ) LQ200111901
Program: Prémie Lumina quaeruntur
Institucionální podpora: RVO:67985823 ; RVO:68378050
Klíčová slova: calanus * fatty acids * krill * mast cells * stereoisomers
Obor OECD: Biochemistry and molecular biology; Biochemistry and molecular biology (UMG-J)
Impakt faktor: 5.820, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1002/mnfr.201901238

Scope The docosahexaenoic acid ester of hydroxy linoleic acid (13-DHAHLA) is a bioactive lipid with anti-inflammatory properties from the family of fatty acid esters of hydroxy fatty acids (FAHFA). Methods and results To explore the biosynthesis of 13-DHAHLA from dietary oils, C57BL/6N mice are gavaged for 8 days with various corn oil/marine oil mixtures containing the same amount of DHA. Plasma levels of omega-3 FAHFAs are influenced by the lipid composition of the mixtures but do not reflect the changes in bioavailability of polyunsaturated fatty acids in plasma. Triacylglycerol-bound DHA and linoleic acid serve as more effective precursors for 13-DHAHLA synthesis than DHA bound in phospholipids or wax esters. Both 13(S)- and 13(R)-DHAHLA inhibit antigen and PGE(2)-induced chemotaxis and degranulation of mast cells to a comparable extent and 13(S)-DHAHLA is identified as the predominant isomer in mouse adipose tissue. Conclusion Here, the optimal nutritional source of DHA is identified, which supports production of anti-inflammatory FAHFAs, as triacylglycerol-based marine oil and also reveals a possible role of triacylglycerols in the synthesis of FAHFA lipokines.
Trvalý link: http://hdl.handle.net/11104/0309128