Počet záznamů: 1  

Doxorubicin‐conjugated iron oxide nanoparticles: surface engineering and biomedical investigation

  1. 1.
    0524743 - ÚMCH 2021 RIV DE eng J - Článek v odborném periodiku
    Oleksa, Viktoriia - Macková, Hana - Patsula, Vitalii - Dydowiczová, Aneta - Janoušková, Olga - Horák, Daniel
    Doxorubicin‐conjugated iron oxide nanoparticles: surface engineering and biomedical investigation.
    ChemPlusChem. Roč. 85, č. 6 (2020), s. 1156-1163. ISSN 2192-6506. E-ISSN 2192-6506
    Grant CEP: GA ČR(CZ) GC20-02177J
    Institucionální podpora: RVO:61389013
    Klíčová slova: antitumor agents * cytotoxicity * drug delivery
    Obor OECD: Polymer science
    Impakt faktor: 2.863, rok: 2020
    Způsob publikování: Omezený přístup
    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cplu.202000360

    Development of therapeutic systems to treat glioblastoma, the most common and aggressive brain tumor, belongs to priority tasks in cancer research. We have synthesized colloidally stable magnetic nanoparticles (D h=336 nm) coated with doxorubicin (Dox) conjugated copolymers of N,N ‐dimethylacrylamide and either N ‐acryloylglycine methyl ester or N ‐acryloylmethyl 6‐aminohexanoate. The terminal carboxyl groups of the copolymers were reacted with alendronate by carbodiimide formation. Methyl ester groups were then transferred to hydrazides for binding Dox by a hydrolytically labile hydrazone bond. The polymers were subsequently bound on the magnetic nanoparticles through bisphosphonate terminal groups. Finally, the anticancer effect of the Dox‐conjugated particles was investigated using the U‐87 glioblastoma cell line in terms of particle internalization and cell viability, which decreased to almost zero at a concentration of 100 μg of particles per ml. These results confirmed that poly(N,N ‐dimethylacrylamide)‐coated magnetic nanoparticles can serve as a solid support for Dox delivery to glioblastoma cells.
    Trvalý link: http://hdl.handle.net/11104/0309384

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.