What antomic features govern personal long-term health risks from breast cancer radiotherapy?

0523892 - ÚJF 2021 RIV US eng J - Článek v odborném periodiku
Kundrát, Pavel - Simonetto, C. - Eidemuller, M. - Remmele, J. - Hannes, R. - Sebb, S. - Wolf, U. - Hildebrandt, G.
What antomic features govern personal long-term health risks from breast cancer radiotherapy?
Radiation Protection Dosimetry. Roč. 186, 2-3 (2019), s. 381-385. ISSN 0144-8420. E-ISSN 1742-3406
Institucionální podpora: RVO:61389005
Klíčová slova: breast neoplasms * radiotherapy * heart dose
Obor OECD: Radiology, nuclear medicine and medical imaging
Impakt faktor: 0.773, rok: 2019
Způsob publikování: Omezený přístup
https://doi.org/10.1093/rpd/ncz236

Breast cancer radiotherapy may in the long term lead to radiation-induced secondary cancer or heart disease. These health risks hugely vary among patients, partially due to anatomy-driven differences in doses deposited to the heart, ipsilateral lung and contralateral breast. We identify four anatomic features that largely cover these dosimetric variations to enable personalized risk estimates. For three exemplary, very different risk scenarios, the given parameter set reproduces 63-74% of the individual risk variability for left-sided breast cancer patients. These anatomic features will be used in the PASSOS software to support decision processes in breast-cancer therapy.
Trvalý link: http://hdl.handle.net/11104/0308175