Gender Differences Involved in the Pathophysiology of the Perinatal Hypoxic-Ischemic Damage

0523652 - FGÚ 2020 RIV CZ eng J - Článek v odborném periodiku
Murden, S. - Borbélyová, V. - Laštůvka, Z. - Mysliveček, J. - Otáhal, Jakub - Riljak, V.
Gender Differences Involved in the Pathophysiology of the Perinatal Hypoxic-Ischemic Damage.
Physiological Research. Roč. 68, Suppl.3 (2019), S207-S2017. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MZd(CZ) NV15-33115A; GA ČR(CZ) GA18-07908S
Institucionální podpora: RVO:67985823
Klíčová slova: gender differences * hypoxia * hypoxic-ischemic encephalopathy * immature brain
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 1.655, rok: 2019
Způsob publikování: Open access
http://www.biomed.cas.cz/physiolres/pdf/2019/68_S207.pdf

Hypoxic-ischemic encephalopathy (HIE) is a neonatal condition that occurs as a consequence of perinatal asphyxia, which is caused by a number of factors, commonly via compression of the umbilical cord, placental abruption, severe meconium aspiration, congenital cardiac or pulmonary anomalies and birth trauma. Experimental studies have confirmed that male rat pups show a higher resistance to HIE treatment. Moreover, the long-term consequences of hypoxia in male are more severe in comparison to female rat pups. These sex differences can be attributed to the pathophysiology of hypoxia-ischemia, whereby studies are beginning to establish such gender-specific distinctions. The current and sole treatment for HIE is hypothermia, in which a reduction in temperature prevents long-term effects, such as cerebral palsy or seizures. However, in most cases hypothermia is not a sufficient treatment as indicated by a high mortality rate. In the present review, we discuss the gender differences within the pathophysiology of hypoxia-ischemia and delve into the role of gender in the incidence, progression and severity of the disease. Furthermore, this may result in the development of potential novel treatment approaches for targeting and preventing the long-term consequences of HIE.
Trvalý link: http://hdl.handle.net/11104/0307970