Lipidated peptides for lowering blood glucose

0523564 - ÚOCHB 2020 RIV eng P - Patentový dokument
Maletínská, Lenka - Železná, Blanka - Kuneš, Jaroslav - Pražienková, Veronika
Lipidated peptides for lowering blood glucose.
2019. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Datum udělení patentu: 16.07.2019. Číslo patentu: US10350271
Grant CEP: GA TA ČR(CZ) TE01020028
Institucionální podpora: RVO:61388963 ; RVO:67985823
Klíčová slova: prolactin-releasing peptide * lipidated * diabetes
Obor OECD: Pharmacology and pharmacy; Endocrinology and metabolism (including diabetes, hormones) (FGU-C)
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=10350271B2&KC=B2&FT=D&ND=4&date=20190716&DB=&locale=en_EP#

Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.
Trvalý link: http://hdl.handle.net/11104/0307904