Introduction to RNAi and miRNA pathways

0523493 - ÚMG 2020 RIV CZ eng M - Část monografie knihy
Svoboda, Petr
RNAi and miRNA pathways in plants II - mobility of small RNAs.
Introduction to RNAi and miRNA pathways. Praha: Karolinum, 2019 - (Svoboda, P.), s. 1-339. ISBN 978-80-246-4372-4
Grant CEP: GA MŠMT LO1220
Institucionální podpora: RVO:68378050
Klíčová slova: dsRNA * siRNA * miRNA * Dicer * Argonaute * RdRP * systemic RNAi * phloem
Obor OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

RNA silencing denotes sequence-specific repression mediated by small RNAs. Plants have arguably the most complex RNA silencing system among eukaryots because of existence of many paralogs of key protein factors, which form in an intricate network of primary and secondary small RNAs, which mediate transcriptional and post-transcriptional effects, which target endogenous protein-coding gene expression, serve as a form of innate immunity targeting viruses, and protect genome integrity by repression of retrotransposons. The complexity of RNA silencing was introduced in an accompanying review. Here, I will focus on mobility of small RNAs in plants, which allows for silencing effects occurring at a different place than where the silencing started. I will discuss different types of mobility of different classes of small RNAs across plant tissues and their biological implications.
Trvalý link: http://hdl.handle.net/11104/0307856