Introduction to RNAi and miRNA pathways

0523489 - ÚMG 2020 RIV CZ eng M - Část monografie knihy
Svoboda, Petr
RNAi and miRNA pathways in arthropods.
Introduction to RNAi and miRNA pathways. Praha: Karolinum, 2019 - (Svoboda, P.), s. 1-339. ISBN 978-80-246-4372-4
Grant CEP: GA MŠMT LO1220
Institucionální podpora: RVO:68378050
Klíčová slova: dsRNA * Dicer * PKR * R2D2 * LOQS * AGO1 * AGO2
Obor OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. While Arthropoda are an extremely large and diverse phylum, research on microRNA (miRNA) and RNA interference (RNAi) pathway in this phylum primarily used the Drosophila melanogaster model system and related species. Notably, both pathways are genetically separated, they utilize dedicated Dicer proteins to produce miRNAs and small interfering RNAs (siRNAs), which are sorted onto different Argonaute effector proteins. This review focuses on the miRNA pathway and pathways initiated by long dsRNA in arthropods. The first part introduces the key molecular players of RNA silencing. The second discussed biological roles of miRNA and dsRNA-induced pathways in Arthropods.
Trvalý link: http://hdl.handle.net/11104/0307851