Advances in Disease Models

0523228 - ÚMG 2020 RIV CZ eng M - Část monografie knihy
Jarošová, Šárka - Zíková, Martina
Molecular subgroups of medulloblastoma. Development of a novel gene mutagenesis and protein tagging strategy.
Advances in Disease Models. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 115-121. ISBN 978-80-88011-06-4
Grant CEP: GA MŠMT LO1419
Institucionální podpora: RVO:68378050
Klíčová slova: medulloblastoma * transcription profile * novel gene mutagenesis * protein tagging strategy
Obor OECD: Biochemistry and molecular biology

Medulloblastoma is the most common malignant brain tumor in children. In recent years, there has been a steady improvement in understanding the genetic and molecular heterogeneity of this tumor, which revealed at least four distinct subgroups of medulloblastomas, each with unique transcription profiles, DNA alterations and clinical outcome. This review summarizes the recent advances in molecular subgroup classification and the associated gene mutations and copy number variations in medulloblastoma.
Trvalý link: http://hdl.handle.net/11104/0307602