Hyaluronan biofilms reinforced with partially deacetylated chitin nanowhiskers: extraction, fabrication, in-vitro and antibacterial properties of advanced nanocomposites

0522175 - ÚMCH 2021 RIV GB eng J - Článek v odborném periodiku
Abdelrahman, R. M. - Abdel-Mohsen, A. M. - Zboncak, M. - Franková, J. - Lepcio, P. - Kobera, Libor - Steinhart, Miloš - Pavliňák, D. - Spotaz, Z. - Sklenářévá, R. - Brus, Jiří - Jancar, J.
Hyaluronan biofilms reinforced with partially deacetylated chitin nanowhiskers: extraction, fabrication, in-vitro and antibacterial properties of advanced nanocomposites.
Carbohydrate Polymers. Roč. 235, 1 May (2020), s. 1-13, č. článku 115951. ISSN 0144-8617. E-ISSN 1879-1344
Institucionální podpora: RVO:61389013
Klíčová slova: nanocomposite biofilm * hyaluronan * nanowhiskers
Obor OECD: Polymer science
Impakt faktor: 9.381, rok: 2020
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0144861720301259?via%3Dihub

Fabrication of nanocomposite biofilms with enhanced mechanical and antibacterial properties was successfully achieved from hyaluronan (HA) and partially deacetylated chitin nanowhiskers (ChNWs) by a casting-evaporation method. The hydrolysis process of chitin showed an important role in the dimensions, stability, and the crystallinity of extracted ChNWs in a time-dependent manner. The volume fraction of ChNWs nanofiller varying from (0.001 to 0.5) exhibited a great influence on the mechanical properties of the biofilms (young modulus, strength) was enhanced by the high load-bearing capacity of NWs compared with net HA film. The antibacterial activity of the nanocomposite biofilms exhibited significant bactericidal activity against different types of bacteria (−/+ gram). HA/ChNWs Nanocomposite biofilms did not show any toxicity against normal human dermal fibroblasts (NHDF) and human primary osteogenic sarcoma (Saos-2) cell lines. The new biofilms with unique properties like edibleness, environmental friendliness, high mechanical properties, antibacterial performance, and non-cytotoxicity that could be used in skin tissue regenerations, and drug delivery applications.
Trvalý link: http://hdl.handle.net/11104/0306944