Počet záznamů: 1
DO3A-Hyp: a new tool for synthesis of MRI probes and more
- 1.0521960 - ÚOCHB 2020 CA eng A - Abstrakt
Kretschmer, Jan - David, Tomáš - Polášek, Miloslav
DO3A-Hyp: a new tool for synthesis of MRI probes and more.
WMIC 2019. World Molecular Imaging Congress. Montreal: World Molecular Imaging Society, 2019. LBP067.
[WMIC 2019. World Molecular Imaging Congress. 04.09.2019-07.09.2019, Montreal]
Institucionální podpora: RVO:61388963
Klíčová slova: gadolinium * MRI contrast agents * peptides * multimodal probes
Obor OECD: Organic chemistry
Multimodal imaging probes that combine different metals within a single molecule are difficult to synthesize because the position of the individual metals is hard to control. This work presents a new amino acid chelator building block (DO3A-Hyp) that allows incorporation of metals into peptides during the peptide synthesis. With this approach, it is possible to tightly control the positions of the metals within the peptide molecule. Peptides containing two different metals with known positions were successfully prepared, paving the way for efficient preparation of multimodal probes or theranostic agents.
Trvalý link: http://hdl.handle.net/11104/0306502
Počet záznamů: 1