Antitumor Carbohydrate-Substituted Arene and Tetrazene Rutheni-um(li) Complexes.

0521916 - ÚCHP 2020 NL eng A - Abstrakt
Pinkas, Jiří - Hrstka, R. - Skoupilová, H. - Karban, Jindřich
Antitumor Carbohydrate-Substituted Arene and Tetrazene Rutheni-um(li) Complexes.
Book of Abstracts. -: -, 2019. OL6.3.2, P109. ISBN N.
[EUROCARB 2019. 30.06.2019-04.06.2019, Leiden]
Grant CEP: GA ČR(CZ) GA17-05838S
Institucionální podpora: RVO:67985858 ; RVO:61388955
Klíčová slova: platinum complexes * clinical practice * tetrazene complexes
Obor OECD: Organic chemistry; Physical chemistry (UFCH-W)

We have prepared a series of Ru(ll) complexes of the general formula [Ru(q6-arene)(q5-Cp*)]+ Cl-, where the arene ligand is the phenyl moiety of benzyl hexopyranosides or benzyl ether-protected hexopyranoses. These complexes had negligible cytotoxicity, but some of them, in particular complex (1), showed anti-migratory and anti-invasive effects in vitro comparable to those of the reference compounds RAPTA-C and RAPTA-T.

Trvalý link: http://hdl.handle.net/11104/0306714