Počet záznamů: 1  

Molecular mechanisms of the interactions of N-(2-hydroxypropyl)methacrylamide copolymers designed for cancer therapy with blood plasma proteins

  1. 1.
    0521863 - ÚMCH 2021 RIV CH eng J - Článek v odborném periodiku
    Janisova, Larisa - Gruzinov, A. - Zaborova, Olga V. - Velychkivska, Nadiia - Vaněk, O. - Chytil, Petr - Etrych, Tomáš - Janoušková, Olga - Zhang, X. - Blanchet, C. - Papadakis, C. M. - Svergun, D. I. - Filippov, S. K.
    Molecular mechanisms of the interactions of N-(2-hydroxypropyl)methacrylamide copolymers designed for cancer therapy with blood plasma proteins.
    Pharmaceutics. Roč. 12, č. 2 (2020), s. 1-9, č. článku 106. E-ISSN 1999-4923
    Grant CEP: GA ČR(CZ) GA17-00973S; GA ČR(CZ) GC15-10527J; GA ČR(CZ) GA17-13283S; GA MŠMT(CZ) LO1507
    Institucionální podpora: RVO:61389013
    Klíčová slova: drug delivery * pHPMA * plasma proteins
    Obor OECD: Polymer science
    Impakt faktor: 6.321, rok: 2020
    Způsob publikování: Open access
    https://www.mdpi.com/1999-4923/12/2/106

    The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) with the most abundant proteins in human blood plasma—namely, human serum albumin (HSA), immunoglobulin G (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and A1—using a combination of small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and nuclear magnetic resonance (NMR). Through rigorous investigation, we present evidence of weak interactions between proteins and polymeric nanomedicine. Such interactions do not result in the formation of the protein corona and do not affect the efficiency of the drug delivery.
    Trvalý link: http://hdl.handle.net/11104/0306713

     
     
Počet záznamů: 1  

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