Stereochemical Study of Chemical Glycosylation with C-3 and C-4 Deoxofluorinated 2-Azido-2-Hexopyranosyl Donors.

0521825 - ÚCHP 2020 NL eng A - Abstrakt
Kurfiřt, Martin - Karban, Jindřich - Červenková Šťastná, Lucie - Dračínský, Martin
Stereochemical Study of Chemical Glycosylation with C-3 and C-4 Deoxofluorinated 2-Azido-2-Hexopyranosyl Donors.
Book of Abstracts. -: -, 2019. OL6.3.2. ISBN N.
[EUROCARB 2019. 30.06.2019-04.06.2019, Leiden]
Grant CEP: GA ČR(CZ) GA17-18203S
Institucionální podpora: RVO:67985858 ; RVO:61388963
Klíčová slova: synthesis * stereoselectivity * carbohydrate
Obor OECD: Organic chemistry; Organic chemistry (UOCHB-X)

Preactivation protocol utilizing diphenyl sulfoxide/triflic anhydride (Ph2S0/Tf20) [3] was used and the results obtained by glycosylation of common model carbohydrate acceptors [4] will be presented. A preparation of mul-tivalent deoxofluorinated glycoclusters employing the results obtained in the model glycosylations will be also presented and a discussion of stereoselectivity based on a computation study of the proposed reaction inter-mediates will be included.
Trvalý link: http://hdl.handle.net/11104/0306386