Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?

0521782 - FGÚ 2020 RIV CZ eng J - Článek v odborném periodiku
Mareš, Pavel - Folbergrová, Jaroslava - Haugvicová, Renata - Kubová, Hana
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Physiological Research. Roč. 68, Suppl.3 (2019), S361-S366. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA18-09296S
Institucionální podpora: RVO:67985823
Klíčová slova: homocysteic acid * seizures * immature rats * NMDA antagonists * AMPA antagonists
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 1.655, rok: 2019
Způsob publikování: Open access
http://www.biomed.cas.cz/physiolres/pdf/2019/68_S361.pdf

Mechanism of ictogenesis of D- and L-stereroisomers of
homocysteic acid was studied in 12-day-old rats by means of
antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-
hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
There was no qualitative difference between the two
stereoisomers in generation of emprosthotonic (flexion) as well
as generalized tonic-clonic seizures. Moderate differences were
observed in the first, nonconvulsive effects of the two isomers.
As generation of the two types of seizures is concerned, NMDA
and AMPA participate in generalized tonic-clonic seizures whereas
NMDA receptors play a dominant role in generation of flexion
seizures.

Trvalý link: http://hdl.handle.net/11104/0306354