Liquid crystalline nanostructures as PEGylated reservoirs of omega-3 polyunsaturated fatty acids: structural insights toward delivery formulations against neurodegenerative disorders

0521653 - FZÚ 2020 RIV US eng J - Článek v odborném periodiku
Angelova, A. - Drechsler, M. - Garamus, V. M. - Angelov, Borislav
Liquid crystalline nanostructures as PEGylated reservoirs of omega-3 polyunsaturated fatty acids: structural insights toward delivery formulations against neurodegenerative disorders.
ACS Omega. Roč. 3, č. 3 (2018), s. 3235-3247. ISSN 2470-1343. E-ISSN 2470-1343
Grant CEP: GA MŠMT EF15_003/0000447
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447
Institucionální podpora: RVO:68378271
Klíčová slova: docosahexaenoic acid * phase-behavior * lipid nanoparticles * internal structure * macromolecular drugs * physical-properties * multidrug delivery * neuronal survival * membrane domain * cubic phase
Obor OECD: Fluids and plasma physics (including surface physics)
Impakt faktor: 2.584, rok: 2018
Způsob publikování: Open access

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are bioactive lipids with considerable impact in medicine and nutrition. These compounds exert structuring effects on the cellular membrane organization, regulate the gene expression, and modulate various signaling cascades and metabolic processes. The purpose of the present work is to demonstrate the structural features of omega-3 PUFA-containing three-dimensional supramolecular lipid assemblies suitable for pharmaceutical applications that require soft porous carriers. We investigate the liquid crystalline structures formed upon mixing of eicosapentaenoic acid (EPA, 20:5) with the lyotropic nonlamellar lipid monoolein and the formation of multicompartment assemblies.
Trvalý link: http://hdl.handle.net/11104/0306242