Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.

0521469 - ÚEB 2020 RIV CH eng J - Článek v odborném periodiku
De Canha, M.N. - Komarnytsky, S. - Langhansová, Lenka - Lall, N.
Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.
Frontiers in Pharmacology. Roč. 10, 30 January (2020), č. článku 1559. ISSN 1663-9812. E-ISSN 1663-9812
Institucionální podpora: RVO:61389030
Klíčová slova: Helcihrysum odoratissimum * Cutibacterium acnes * Antimicrobial activity
Obor OECD: Medical biotechnology related ethics
Impakt faktor: 5.811, rok: 2020
Způsob publikování: Open access
https://www.frontiersin.org/articles/10.3389/fphar.2019.01559/abstract

The Gram-positive bacterium Cutibacterium acnes (previously Propionibacterium acnes), plays an important role in the pathogenesis and progression of the dermatological skin disorder acne vulgaris. The methanolic extract of Helichrysum odoratissimum (HO-MeOH) was investigated for its ability to target bacterial growth and pathogenic virulence factors associated with acne progression. The GC-MS analysis of HO-MeOH identified α-humulene, α-curcumene and carophyllene as major constituents, which correlated with previous reports. The HO-MeOH extract exhibited potent antimicrobial activity against C. acnes (ATCC 6919) with an MIC of 7.81 µg/ml. It enhanced the antimicrobial activity of benzoyl peroxide (BPO). The extract showed high specificity against C. acnes cell aggregation at sub-inhibitory concentrations, preventing biofilm formation. Mature C. acnes biofilms were disrupted at a sub-inhibitory concentration of 3.91 µg/ml.
Trvalý link: http://hdl.handle.net/11104/0306085