Mitochondria-driven elimination of cancer and senescent cells

0520732 - BTÚ 2020 RIV DE eng J - Článek v odborném periodiku
Hubáčková, Soňa - Novais, Silvia Magalhaes - Davidová, Eliška - Neužil, Jiří - Rohlena, Jakub
Mitochondria-driven elimination of cancer and senescent cells.
Biological Chemistry. Roč. 400, č. 2 (2019), s. 141-148. ISSN 1431-6730. E-ISSN 1437-4315
Grant CEP: GA ČR GA17-20904S; GA ČR GA16-22823S; GA ČR(CZ) GA18-02550S; GA ČR(CZ) GC17-01192J; GA ČR GA16-12719S; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036
Klíčová slova: cellular senescence * oxidative stress * contributes * suppression * respiration
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.270, rok: 2019
Způsob publikování: Open access
https://www.nature.com/articles/s41418-018-0118-3

Mitochondria and oxidative phosphorylation (OXPHOS) are emerging as intriguing targets for the efficient elimination of cancer cells. The specificity of this approach is aided by the capacity of non-proliferating non-cancerous cells to withstand oxidative insult induced by OXPHOS inhibition. Recently we discovered that mitochondrial targeting can also be employed to eliminate senescent cells, where it breaks the interplay between OXPHOS and ATP transporters that appear important for the maintenance of mitochondrial morphology and viability in the senescent setting. Hence, mitochondria/OXPHOS directed pharmacological interventions show promise in several clinically-relevant scenarios that call for selective removal of cancer and senescent cells.
Trvalý link: http://hdl.handle.net/11104/0305579