MicroRNAs as biomarkers of harmful environmental and occupational exposures: a systematic review

0519767 - BC 2020 RIV GB eng J - Článek v odborném periodiku
Kotsyfakis, Michalis - Patelarou, E.
MicroRNAs as biomarkers of harmful environmental and occupational exposures: a systematic review.
Biomarkers. Roč. 24, č. 7 (2019), s. 623-630. ISSN 1354-750X. E-ISSN 1366-5804
Grant CEP: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759
Institucionální podpora: RVO:60077344
Klíčová slova: short-term exposure * air-pollution * expression * mirna * population * profiles * benzene * Air pollution * biomarker * environmental exposure * heavy metals * microRNA * organic compounds * particulate matter
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.070, rok: 2019
Způsob publikování: Omezený přístup
https://www.tandfonline.com/doi/full/10.1080/1354750X.2019.1652348?scroll=top&needAccess=true

Environmental exposure is a growing public health burden associated with several negative health effects. An estimated 4.2 million deaths occur each year from ambient air pollution alone. Biomarkers that reflect specific exposures have the potential to measure the real integrated internal dose from all routes of complex environmental exposure. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have been studied as biomarkers in various diseases and have also shown potential as environmental exposure biomarkers. Here, we review the available human epidemiological and experimental evidence of miRNA expression changes in response to specific environmental exposures including airborne particulate matter. In doing so, we establish that miRNA exposure biomarker development remains in its infancy and future studies will need to carefully consider biological and analytical 'design rules' in order to facilitate clinical translation.
Trvalý link: http://hdl.handle.net/11104/0304761