Prodrugs of glutamine analogs

0519635 - ÚOCHB 2020 RIV eng P - Patentový dokument
Slusher, B. S. - Rais, R. - Tenora, Lukáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of glutamine analogs.
2019. Vlastník: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Datum udělení patentu: 02.07.2019. Číslo patentu: US10336778
Institucionální podpora: RVO:61388963
Klíčová slova: 6-diazo-5-oxo-L-norleucine (DON) * prodrugs * cancer
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20190702&DB=&locale=en_EP&CC=US&NR=10336778B2&KC=B2&ND=4#

The disclosure provides compounds having formula (I) and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
Trvalý link: http://hdl.handle.net/11104/0306509