Mannitol treatment is not effective in therapy of rabies virus infection in mice

0519413 - BC 2020 RIV GB eng J - Článek v odborném periodiku
Dufková, L. - Širmarová, J. - Salát, J. - Hönig, Václav - Palus, Martin - Růžek, Daniel - Fooks, A. R. - Mansfield, K. L. - Tordo, N. - Jochmans, D. - Neyts, J. - Martina, B. - Koraka, P. - Osterhaus, D. M. E. … celkem 15 autorů
Mannitol treatment is not effective in therapy of rabies virus infection in mice.
Vaccine. Roč. 37, č. 33 (2019), s. 4710-4714. ISSN 0264-410X. E-ISSN 1873-2518
Institucionální podpora: RVO:60077344
Klíčová slova: blood-brain-barrier * innate immune-responses * central-nervous-system * permeability * delivery * Rabies * Blood-brain barrier * Mannitol * Therapy
Obor OECD: Immunology
Impakt faktor: 3.143, rok: 2019
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0264410X17317814?via%3Dihub

Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice. (C) 2017 Elsevier Ltd. All rights reserved.
Trvalý link: http://hdl.handle.net/11104/0304385