0519144 - ÚFCH JH 2020 RIV CH eng M - Část monografie knihy
Bald, I. - Čurík, Roman - Kopyra, J. - Tarana, Michal
Dissociative Electron Attachment to Biomolecules.
Nanoscale Insights into Ion-Beam Cancer Therapy. Cham: Springer, 2016 - (Solovyov, A.), s. 159-207. ISBN 978-3-319-43028-7
Institucionální podpora: RVO:61388955
Klíčová slova: Low-energy electrons * Deoxyribonucleic acid * Electron attachment
Obor OECD: Physical chemistry

During the last two decades it became clear that a significant fraction of
the biological cellular damage caused by high-energy radiation is actually due to
reactions induced by low-energy electrons ( <20 eV). In this energy regime electrons
can efficiently decotnpose 1nolecules such as DNA or DNA building blocks
by dissociative electron attachment (DEA). Experin,ents on single DNA building
blocks have been perfonned in the gas phase revealing that DEA can proceed with
remarkable site selectivity. Low-energy electron-induced DNA strand breakage is
typically investigated using plasntid DNA in the condensed phase. Very recently, a
pronounced dependence of electron induced DNA strand breakage on the nucleotide
sequence was found using different experimental approaches suggesting that at least
part of the observed strand breaks are due to initial electron attachment to the nucleobases.
Currently, a strong research focus is on the funda1nental understanding of
DEA to therapeutically administered radiosensitizers. In the near future DEA to
novel potential radioseusitizers will be explored, and tbe electron induced dan1age
of biomolecules withi11 complex environ1nents has to be investigated. Considerable
attention has been paid to the theoretical research of the DEA in the context of the
DNA da1nage. With respect to this, the theoretical part of the chapter reviews all
the co1nputational approaches that have been used to study DEA to bio1nolecules
over the last decade. These approaches are divided into two classes.
Trvalý link: http://hdl.handle.net/11104/0304163