Počet záznamů: 1  

DNA repair capacity and response to treatment of colon cancer

  1. 1.
    0518156 - ÚEM 2020 RIV GB eng J - Článek v odborném periodiku
    Vodička, Pavel - Vodenková, Soňa - Buchler, T. - Vodičková, Ludmila
    DNA repair capacity and response to treatment of colon cancer.
    Pharmacogenomics. Roč. 20, č. 17 (2019), s. 1225-1233. ISSN 1462-2416. E-ISSN 1744-8042
    Grant CEP: GA MZd(CZ) NV15-27580A; GA ČR(CZ) GA18-09709S; GA MZd(CZ) NV18-03-00199
    Institucionální podpora: RVO:68378041
    Klíčová slova: colon cancer * DNA repair * DNA repair capacity
    Obor OECD: Human genetics
    Impakt faktor: 2.339, rok: 2019
    Způsob publikování: Omezený přístup
    https://www.futuremedicine.com/doi/10.2217/pgs-2019-0070

    DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed.
    Trvalý link: http://hdl.handle.net/11104/0303331

     
     
Počet záznamů: 1  

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