Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors

0517550 - FGÚ 2020 RIV JP eng J - Článek v odborném periodiku
Vavřínová, Anna - Behuliak, Michal - Bencze, Michal - Vodička, Martin - Ergang, Peter - Vaněčková, Ivana - Zicha, Josef
Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors.
Hypertension Research. Roč. 42, Dec (2019), s. 1872-1882. ISSN 0916-9636. E-ISSN 1348-4214
Grant CEP: GA ČR(CZ) GJ16-10349Y; GA MZd(CZ) NV15-25396A
Institucionální podpora: RVO:67985823
Klíčová slova: guanethidine * catecholamines * blood pressure response * vascular wall innervation * adrenal medulla
Obor OECD: Cardiac and Cardiovascular systems
Impakt faktor: 2.941, rok: 2019
Způsob publikování: Omezený přístup
https://www.nature.com/articles/s41440-019-0319-2

The effect of chemical sympathectomy on cardiovascular parameters and the compensatory role of adrenal hormones, the renin–angiotensin system, and cardiovascular sensitivity to vasoconstrictors were studied in spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats. Sympathectomy was induced in 20-week-old rats by daily intraperitoneal guanethidine administration (30 mg/kg b.w.) for 2 weeks. Basal blood pressure (BP), heart rate (HR), and restraint stress-induced cardiovascular changes were measured by radiotelemetry. The BP response to catecholamines was determined in rats with implanted catheters. Sympathectomy decreased BP only transiently, and after 14-day guanethidine treatment, BP returned to basal values in both strains. Sympathectomy permanently lowered HR, improved baroreflex sensitivity, and decreased the low-frequency domain of systolic blood pressure variability (a marker of vascular sympathetic activity). Guanethidine also attenuated the BP and HR responses to restraint stress. On the other hand, the BP response to catecholamines was augmented in sympathectomized rats, and this was not due to the de novo synthesis of vascular adrenergic receptors. Sympathectomy caused adrenal enlargement, enhanced the expression of adrenal catecholamine biosynthetic enzymes, and elevated plasma adrenaline levels in both strains, especially in WKY rats. Guanethidine also increased the plasma levels of aldosterone and corticosterone in WKY rats only. In conclusion, sympathectomy produced a transient decrease in BP, a chronic decrease in HR and improvement in baroreflex sensitivity. The effect of sympathectomy on BP was counteracted by increased vascular sensitivity to catecholamines in WKY rats and SHRs and/or by the enhanced secretion of adrenal hormones, which was more pronounced in WKY rats.
Trvalý link: http://hdl.handle.net/11104/0302885