Počet záznamů: 1  

Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

  1. 1.
    0512006 - ÚŽFG 2020 RIV GB eng J - Článek v odborném periodiku
    Lind, A. L. - Lai, Y. Y. - Mostovoy, Y. - Holloway, A. K. - Iannucci, A. - Mak, A. C. Y. - Fondi, M. - Orlandini, V. - Eckalbar, W. L. - Milan, M. - Rovatsos, Michail - Kichigin, I. G. - Makunin, A. I. - Johnson Pokorná, Martina - Altmanová, Marie - Trifonov, V. A. - Schijlen, E. - Kratochvíl, L. - Fani, R. - Velenský, P. - Řehák, I. - Patarnello, T. - Jessop, T. S. - Hicks, J. W. - Ryder, O. - Mendelson, J. R. - Ciofi, C. - Kwok, P.Y. - Pollard, K. S. - Bruneau, B. G.
    Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.
    Nature Ecology & Evolution. Roč. 3, č. 8 (2019), s. 1241-1252. ISSN 2397-334X. E-ISSN 2397-334X
    Institucionální podpora: RVO:67985904
    Klíčová slova: Komodo dragon * monitor lizards
    Obor OECD: Genetics and heredity (medical genetics to be 3)
    Impakt faktor: 12.543, rok: 2019
    Způsob publikování: Open access
    https://www.nature.com/articles/s41559-019-0945-8

    Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.
    Trvalý link: http://hdl.handle.net/11104/0302229

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.