Porphyrin‑silver Nanoparticles Hybrids: Synthesis, Characterization and Antibacterial Activity.

0511844 - ÚCHP 2020 RIV NL eng J - Článek v odborném periodiku
Elashnikov, R. - Radocha, M. - Panov, Illia - Rimpelová, S. - Ulbrich, P. - Michalcová, A. - Švorčík, V. - Lyutakov, O.
Porphyrin‑silver Nanoparticles Hybrids: Synthesis, Characterization and Antibacterial Activity.
Materials Science & Engineering C-Materials for Biological Applications. Roč. 102, SEP 2019 (2019), s. 192-199. ISSN 0928-4931. E-ISSN 1873-0191
Institucionální podpora: RVO:67985858
Klíčová slova: silver nanoparticles * porphyrin * light-triggered
Obor OECD: Organic chemistry
Impakt faktor: 5.880, rok: 2019
Způsob publikování: Omezený přístup

The preparation of light-activated hybrid antibacterial agent combining the porphyrin molecules, bound to the silver nanoparticles (AgNPs) surface is reported. AgNPs were synthesized by N-methyl-2-pyrrolidone-initiated reduction without additional reducing agents. The chemical structure of protoporphyrin IX was modified with the aim to introduce thiol groups. The size distribution and shape features of AgNPs were checked using TEM and HRTEM microscopies. The introduction of thiol groups into the porphyrin was proved by IR spectroscopy. The AgNPs-porphyrin binding was performed in solution and confirmed by fluorescence quenching, Raman spectroscopy and energy-filtered transmission electron microscopy (EFTEM). The antibacterial tests were performed against S. epidermidis and E. coli upon to LED illumination and in the dark. The synergetic effect of AgNPs and porphyrin as well as light activation of the created antibacterial conjugates were observed.
Trvalý link: http://hdl.handle.net/11104/0302091