Population incidence of congenital microcephaly in the Czech Republic

0511787 - ÚI 2020 GB eng A - Abstrakt
Friedová, N. - Šípek jr., A. - Gregor, V. - Šípek, A. - Klaschka, Jan - Malý, Marek
Population incidence of congenital microcephaly in the Czech Republic.
European Journal of Human Genetics. Springer. Roč. 27, Suppl. 2 (2019), s. 1445-1446. ISSN 1018-4813. E-ISSN 1476-5438.
[ESHG 2019: European Human Genetics Conference /52./. 15.06.2019-18.06.2019, Gothenburg]
Grant CEP: GA MZd NV17-29622A
Institucionální podpora: RVO:67985807
https://www.nature.com/articles/s41431-019-0494-2

ABSTRACT No. P09.077D. INTRODUCTION: Microcephaly is defined as a congenital anomaly of the central nervous system which is characterized by the decreased head circumference. The exact definition may be slightly different for different countries, in the Czech Republic the microcephaly is defined as the head circumference under the 3rd percentile for specific age and sex of the particular individual. METHODS: We present a retrospective epidemiological study of the incidence of microcephaly (ICD-10 code Q02) in the livebirths and in the prenatally diagnosed cases in the Czech Republic (time period 1994-2015). The data were obtained from the National Registry of Congenital Anomalies. During the selected time period the registry included only the cases of congenital anomalies in children under 15 years of age. Surveillance program is population based. RESULTS: There were 2 140 009 livebirths in the Czech Republic during 1994-2015 time period. The average incidence of microcephaly was 1.07 per 10 000 of livebirths (highest was 1.72 in 2002 and lowest was 0.33 in 1998). The anomaly was more common amongst girls - F/M ratio was 1.32/1.0. Only few cases of microcephaly were diagnosed prenatally (average incidence in prenatal diagnostics 0.12 per 10 000). DISCUSSION: The overall incidence of microcephaly in the Czech Republic is low - compared to the data from other population based registries. We believe, that the clinicians tend to report only severe cases of congenital microcephaly with neurological symptoms.
Trvalý link: http://hdl.handle.net/11104/0302036