Practical sample pretreatment techniques coupled with capillary electrophoresis for real samples in complex matrices

0510624 - ÚIACH 2021 RIV GB eng J - Článek v odborném periodiku
Járvás, G. - Guttman, A. - Miekus, N. - Baczek, T. - Jeong, S. - Chung, D. S. - Pätoprstý, V. - Masár, M. - Hutta, M. - Datinská, Vladimíra - Foret, František
Practical sample pretreatment techniques coupled with capillary electrophoresis for real samples in complex matrices.
TrAC-Trends in Analytical Chemistry. Roč. 122, JAN (2020), č. článku 115702. ISSN 0165-9936. E-ISSN 1879-3142
Grant CEP: GA MŠMT(CZ) 8F17003
Institucionální podpora: RVO:68081715
Klíčová slova: capillary electrophoresis * liquid phase separation * microreactors * sample pretreatment
Obor OECD: Analytical chemistry
Impakt faktor: 12.296, rok: 2020
Způsob publikování: Omezený přístup

By coupling a sample pretreatment technique of sample clean up and enrichment power with capillary electrophoresis (CE) of high-performance separation, the task of analyzing trace analytes in a complex matrix such as a biological sample can be carried out successfully with ease. This review aims for providing an overview of strategies to couple sample pretreatment techniques with capillary and related microscale (e.g., microchip) electrophoresis, practically adoptable in an automatic manner, without requiring serious modification of existing instruments to install sophisticated interfaces. In-line sample pretreatment techniques based on liquid phase microextraction performed before sample injection and on-line sample preconcentration techniques performed during or after sample injection are discussed with emphasis on the applicability to samples of high conductivity, commonly encountered for biological samples. An overview of the recent developments in microfluidic immobilized enzymatic microreactors which fit excellently to microchip CE is also given.
Trvalý link: http://hdl.handle.net/11104/0301047