Počet záznamů: 1
Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents
- 1.0509934 - ÚACH 2020 RIV US eng J - Článek v odborném periodiku
Šťastný, Martin - Štengl, Václav - Štenglová Netíková, I. R. - Šrámová Slušná, Michaela - Janoš, P.
Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents.
PLoS ONE. Roč. 14, č. 10 (2019), č. článku 0223117. ISSN 1932-6203. E-ISSN 1932-6203
Institucionální podpora: RVO:61388980
Klíčová slova: titanium dioxide nanoparticle * anthracyclines * sodium hydroxide
Obor OECD: Inorganic and nuclear chemistry
Impakt faktor: 2.740, rok: 2019
Způsob publikování: Open access
Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5-120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively.
Trvalý link: http://hdl.handle.net/11104/0300522
Název souboru Staženo Velikost Komentář Verze Přístup Removal.pdf 0 5 MB CC BY 4.0 licence Vydavatelský postprint povolen
Počet záznamů: 1