The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved

0508394 - ÚEM 2020 RIV GB eng J - Článek v odborném periodiku
Čejka, Čestmír - Kubinová, Šárka - Čejková, Jitka
The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.
Free Radical Research. Roč. 53, č. 3 (2019), s. 237-247. ISSN 1071-5762. E-ISSN 1029-2470
Grant CEP: GA MŠMT(CZ) LO1309
Institucionální podpora: RVO:68378041
Klíčová slova: molecular hydrogen * ocular diseases and injuries * reactive oxygen species
Obor OECD: Ophthalmology
Impakt faktor: 2.839, rok: 2019
Způsob publikování: Omezený přístup
https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1582770

Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Molecular hydrogen (H-2) is very suitable for this purpose due to its unique properties. H-2 is the only antioxidant that crosses the blood-brain and blood-ocular barriers. It quickly penetrates through tissue due to its small molecular size and effectively removes ROS, mainly hydroxyl radicals and peroxynitrite. Apart from its antioxidant effects, H-2 also displays anti-inflammatory, antiapoptotic, cytoprotective and mitohormetic properties. A significant advantage of H-2 is its nontoxicity, even when applied at high concentrations. In this review, we present the results of studies utilising H-2 in the treatment of ocular diseases involving oxidative stress. These results, obtained in experimental animals as well as in human clinical studies, show that the suppression of oxidative stress by H-2 treatment leads to the prevention or improvement of ocular diseases. In severe degenerative diseases, H-2 slows disease progression.
Trvalý link: http://hdl.handle.net/11104/0302791