Poly-epsilon-caprolactone and polyvinyl alcohol electrospun wound dressings: adhesion properties and wound management of skin defects in rabbits

0508388 - ÚEM 2020 RIV GB eng J - Článek v odborném periodiku
Buzgo, Matej - Plencner, Martin - Rampichová, Michala - Litvinec, Andrej - Prosecká, Eva - Staffa, Andrea - Královič, Martin - Filová, Eva - Doupnik, M. - Lukášová, Věra - Vocetková, Karolína - Anderová, J. - Kubíková, T. - Zajíček, R. - Lopot, F. - Jelen, K. - Tonar, Z. - Amler, E. - Divín, Radek - Fiori, F.
Poly-epsilon-caprolactone and polyvinyl alcohol electrospun wound dressings: adhesion properties and wound management of skin defects in rabbits.
Regenerative Medicine. Roč. 14, č. 5 (2019), s. 423-445. ISSN 1746-0751. E-ISSN 1746-076X
Grant CEP: GA ČR(CZ) GA15-15697S; GA MŠMT(CZ) LO1508; GA MŠMT(CZ) LO1309
Institucionální podpora: RVO:68378041
Klíčová slova: electrospinning * in vivo * nanofibers * polycaprolactone
Obor OECD: Biomaterials (as related to medical implants, devices, sensors)
Impakt faktor: 2.598, rok: 2019
Způsob publikování: Omezený přístup
https://www.futuremedicine.com/doi/10.2217/rme-2018-0072

This study evaluates the effect of electrospun dressings in critical sized full-thickness skin defects in rabbits. Materials & methods: Electrospun poly-epsilon-caprolactone (PCL) and polyvinyl alcohol (PVA) nanofibers were tested in vitro and in vivo. Results: The PCL scaffold supported the proliferation of mesenchymal stem cells, fibroblasts and keratinocytes. The PVA scaffold showed significant swelling, high elongation capacity, limited protein adsorption and stimulation of cells. Nanofibrous dressings improved wound healing compared with the control group in vivo. A change of the PCL dressing every 7 days resulted in a decreased epithelial thickness and type I collagen level in the adhesive group, indicating peeling off of the newly formed tissue. In the PVA dressings, the exchange did not affect healing. Conclusion: The results demonstrate the importance of proper dressing exchange.
Trvalý link: http://hdl.handle.net/11104/0299393