Počet záznamů: 1
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
- 1.0508104 - BC 2020 RIV US eng J - Článek v odborném periodiku
Meccariello, A. - Salvemini, M. - Primo, P. - Hall, B. - Koskinioti, P. - Dalíková, Martina - Gravina, A. - Gucciardino, M. A. - Forlenza, F. - Gregoriou, M.-E. - Ippolito, D. - Monti, S. M. - Petrella, V. - Perrotta, M. M. - Schmeing, S. - Ruggiero, A. - Scolari, F. - Giordino, E. - Tsoumani, K. T. - Marec, František - Windibichler, N. - Arunkumar, K. P. - Bourtzis, K. - Mathiopoulos, K. D. - Ragoussis, J. - Vitaglino, L. - Tu, Z. - Papathanos, P. A. - Robinson, M. D. - Saccone, G.
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests.
Science. Roč. 365, č. 6460 (2019), s. 1457-1460. ISSN 0036-8075. E-ISSN 1095-9203
Grant CEP: GA ČR(CZ) GA17-13713S
Grant ostatní: GA ČR(CZ) GA17-17211S
Institucionální podpora: RVO:60077344
Klíčová slova: medfly * male sex determination * Y chromosome
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 41.846, rok: 2019
Způsob publikování: Omezený přístup
https://science.sciencemag.org/content/365/6460/1457
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, Medfly) we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.
Trvalý link: http://hdl.handle.net/11104/0300857
Počet záznamů: 1