Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one

0507770 - ÚOCHB 2020 RIV GB eng J - Článek v odborném periodiku
Naidoo, D. - Pošta, Martin - Roy, A. - Kulkarni, M. - Van Staden, J.
Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one.
Phytochemistry. Roč. 163, Jul (2019), s. 187-194. ISSN 0031-9422. E-ISSN 1873-3700
Institucionální podpora: RVO:61388963
Klíčová slova: monoamine oxidase * acetylcholinesterase * karrikinolide * trimethylbutenolide * smoke * synthesis
Obor OECD: Organic chemistry
Impakt faktor: 3.044, rok: 2019
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S0031942218307982?via%3Dihub

Smoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR(1) displayed the most encouraging activity returning IC50 values of 13.75 +/- 0.001 mu M and 0.03 +/- 0.02 mu M for monoamine oxidase A and B and 0.08 +/- 0.006 mu M for acetylcholinesterase. Neuroprotective butenolides may be particularly useful in the treatment of depressive disorders, Alzheimer's and Parkinson's diseases.
Trvalý link: http://hdl.handle.net/11104/0298740