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NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans
- 1.0507580 - ÚFCH JH 2020 RIV CH eng J - Článek v odborném periodiku
Pelclová, D. - Navrátil, Tomáš - Kačerová, T. - Zámostná, K. - Fenclová, Z. - Vlčková, Š. - Kačer, P.
NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans.
Nanomaterials. Roč. 9, č. 6 (2019), č. článku 888. E-ISSN 2079-4991
Grant CEP: GA ČR(CZ) GA18-02079S
Institucionální podpora: RVO:61388955
Klíčová slova: Exhaled breath condensate (EBC) * Inflammation * Nanoparticles absorption * NanoTiO 2 * Nanotoxicology * Oxidative stress * Plasma
Obor OECD: Physical chemistry
Impakt faktor: 4.324, rok: 2019
Způsob publikování: Open access
Licensee MDPI, Basel, Switzerland. The present pilot study tested the efficiency of nanoTiO2 sunscreen to prevent the oxidative stress/inflammation caused by ultraviolet (UV) radiation using biomarkers in subjects’ blood, urine, and exhaled breath condensate (EBC). In addition, the skin absorption of nanoTiO2 was studied. Six identical subjects participated in three tests: (A) nanoTiO2 sunscreen, (B)UV radiation, and (C) sunscreen +UV. The first sampleswere collected before the test and the second after sunscreen application and/or UV exposure. On day 4, the third sampleswere collected, and the sunscreenwaswashed off, and the fourth sampleswere collectedonday11. The followingbiomarkersweremeasured: malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, aldehydes C6-C12, 8-iso-Prostaglandin F2α, o-tyrosine, 3-chlorotyrosine, 3-nitrotyrosine, 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, 5-hydroxymethyl uracil, and leukotrienes, using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Titania was measured using inductively coupled plasma mass spectrometry and TiO2 nanoparticles by transmission and scanning electron microscopy. Sunscreen alone did not elevate the markers, but UV increased the biomarkers in the plasma, urine, and EBC. The sunscreen prevented skin redness, however it did not inhibit the elevation of oxidative stress/inflammatory markers. Titania and nanoTiO2 particles were found in the plasma and urine (but not in the EBC) in all sunscreen users, suggesting their skin absorption.
Trvalý link: http://hdl.handle.net/11104/0298568
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