A single spike deteriorates synaptic conductance estimation

0506646 - FGÚ 2020 RIV IE eng J - Článek v odborném periodiku
Kobayashi, R. - Nishimaru, H. - Nishijo, H. - Lánský, Petr
A single spike deteriorates synaptic conductance estimation.
Biosystems. Roč. 161, Nov (2017), s. 41-45. ISSN 0303-2647. E-ISSN 1872-8324
Grant CEP: GA ČR(CZ) GA15-08066S
Institucionální podpora: RVO:67985823
Klíčová slova: synaptic conductance estimation * single neuron models * Ornstein-Uhlenbeck process
Obor OECD: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Impakt faktor: 1.619, rok: 2017
Způsob publikování: Open access
https://doi.org/10.1016/j.biosystems.2017.07.007

We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin-Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.
Trvalý link: http://hdl.handle.net/11104/0297854